Synthesis of trypanocidal tetrahydrofuran lignans

Biosynthesis of tetrahydrofuran lignans in Virola surinamensis

Busaliol and Busalicifol, Two New Tetrahydrofuran Lignans from Bupleurum Salicifolium

-Three tetrahydrofuran lignans [l-3} were obtained from the leaves of Bupleu17lm salici!olium, of which busaliol {l} and busalicifol {2} are novel. Their structures were determined by spectral and chemical methods. Also obtained in this investigation were a number of other lignans, coumarins, a polyacetylene, and a triterpenoid, all of known structure. Bupleurum salicifolium Sol!. ex Lowe (Umbe...

New cytotoxic tetrahydrofuran- and dihydrofuran-type lignans from the stem of Beilschmiedia tsangii.

Five new compounds including two tetrahydrofuran-type lignans, beilschmin A and beilschmin B, a dihydrofuran-type lignan, beilschmin C, and two 1-phenylbutyl benzoates, tsangin A and tsangin B, together with thirteen known compounds have been isolated from the stem of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beil...

Synthesis of 3,4-dibenzyltetrahydrofuran lignans (9,9'-epoxylignanes).

Different strategies for the racemic or enantiospecific total syntheses of plant and mammalian 3,4-dibenzyltetrahydrofuran lignans are reviewed and compared. The multi-step approaches have various key step strategies: Diels-Alder reactions, Stobbe condensations, Michael additions, alkylations, nitrile oxide cycloadditions, radical cyclisations, dianion and oxidative couplings.

Synthesis and Trypanocidal Properties of New Coumarin-Chalcone Derivatives

1CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua Campo Alegre 687, 4169-007 Porto, Portugal 2Department of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Science, University of Chile, Casilla 233, Santiago, Chile 3Departamento of Molecular and Clinical Pharmacology, Faculty of Medicine, University of Chile, Santiago, Chil...